Chang’s newest text has been shortened, streamlined and optimized for a one-semester introductory course in physical chemistry for students of biosciences. Most students enrolled in this course have taken general chemistry, organic chemistry, and a year of physics and calculus. Only basic skills of differential and integral calculus are required for understanding the equations. For premedical students, this text will form the basis for taking courses like physiology in medical school. For those intending to pursue graduate study in biosciences, the material presented here will serve as an introduction to topics in biophysical chemistry courses, where more advanced texts such as those by Gennis, van Holde, and Cantor & Schimmel are used. The author’s aim is to emphasize understanding physical concepts rather than focusing on precise mathematical development or on actual experimental details. The end-of-chapter problems have both physiochemical and biological applications.