New Clinical Genetics, fourth edition

A guide to genomic medicine

Andrew Read, Prof Dian Donnai

Price: £33.99 , $50.99, €40.79

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Format: Ebook

Publication date: October 22, 2020

Pages: 468 pages

ISBN: 9781911510741 Related titles: ,

Other editions available: Paperback


New Clinical Genetics continues to offer the most innovative case-based approach to investigation, diagnosis, and management in clinical genetics.

New Clinical Genetics is used worldwide as a textbook for medical students, but also as an essential guide to the field for genetic counselors, physician assistants, clinical and nurse geneticists, and students studying healthcare courses allied to medicine. Readers love the integrated case-based approach which ties the science to real-life clinical scenarios to really aid understanding.

Clinical genetics is a fast-moving field and there have been many advances in the few years since the previous edition was published. This 4th edition has been completely updated and revised to reflect new science, new techniques and new ways of thinking.

Nowhere is this more clear than in the chapter discussing genetics services which is now significantly expanded to reflect the increasing role of genomic medicine and the use of multidisciplinary teams in the management of patients with genetic disorders.

The unique case-based structure and format remains the same, but substantial new material has been added to cover:

  • polygenic risk scores – now starting to become useful clinical service tools
  • preimplantation diagnosis
  • noninvasive prenatal diagnosis
  • companion diagnostics for prescribed drugs
  • liquid biopsies in cancer
  • epigenetics and gene regulation
  • the widespread use of next-generation sequencing as a routine diagnostic tool
  • the checking of a patient’s whole exome for the cause of their problem

Examination Copies

You can order an electronic or paper exam copy (or both if you prefer).

If you just want to have a quick skim through the book, we would be grateful if you would start with an electronic copy – it saves a lot of money, time and resources for us

To request an electronic exam copy, please fill in the electronic exam copy form.

If you will seriously consider recommending New Clinical Genetics as your main text, then we will be pleased to provide you with a paper exam copy. 

To request a paper exam copy, email Simon Watkins ( with the following information:
– Course name
– Course start date
– Enrollment (number of students taking the class)
– Current recommended texts
– Your mailing address (including home address if you are working from home)

(Exam copies are sent only to academic staff/faculty teaching an appropriate course at a recognised instituion and are sent at our sole discretion). 

Online-only Chapter 15
To access the free online-only chapter, Chapter 15 How to use linkage to map a disease gene, please click on the ‘resources’ tab above.

1 What can we learn from a family history?
2 How can a patient's chromosomes be studied?
3 How do genes work?
4 How can a patient's DNA be studied?
5 How can we check a patient's DNA for gene mutations?
6 What do mutations do?
7 Is cancer genetic?
8 How do researchers identify genes for mendelian diseases?
9 Why are some conditions common and others rare?
10 How do our genes affect our metabolism, drug responses and immune system?
11 How are genes regulated?
12 When is screening useful?
13 Should we be testing for genetic susceptibility to common diseases?
14 What clinical services are available for families with genetic disorders?
15 How to use linkage to map a disease gene
Disease index

Incredible Book with Great Teaching Capability
‘This book is incredibly well put together. The author gives both a typical textbook description of material, as well as a case-study based presentation. There are questions at the end of each chapter to help check your understanding. The only thing I don’t like is that there are no provided answers to these questions, only basic hints. However, I recognize why the author did this as it provides a better academic challenge to the reader.

I didn’t even buy this for a class. I bought this to read for personal enjoyment and have not been disappointed! Especially for how cheap this is (for a textbook) this is a steal!' Amazon reviewer

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